Comprehensive Chemical Exposure Framework

Title Page

1.0 Introduction

2.0 Literature Review

3.0 Model Framework

4.0 Scenarios
4.1 Life Stages
4.2 Scenario 1
    Model Flow Diagram 1
4.3 Scenario 2
    Model Flow Diagram 2
4.4 Scenario 3
    Model Flow Diagram 3
4.5 Scenario 4
    Model Flow Diagram 4
4.6 Process Flow
4.7 Gap Analysis

5.0 Qualitative Analysis

6.0Recommendations

7.0 References

Appendix A

The following Scenario 4 Process Flow Diagram illustrates
the mapping between the models and the process numbers.
Select a model or model description from the table below (ordered alphabetically),
and the corresponding processes on the diagram will be highlighted.
Butoxyacetic acid metabolite
CONTAMW
Dust resuspension
Fuel spill frequency & volume
IAQX for Compound A
indoor smoke emission
Micro-Environmental Air Transport Outdoors
Paint spill frequency & volume
Partitioning between vapor and particle phase
PBPD for adult male
PBPK for adult male
PROMISE for Spills from Compounds B and E
Source emission model(s) for fueling, combustion and servicing
THERdbASE
WPEM for Compound B

Figure 4.6.12 Scenario 4 Process Framework: Exposure of Father to Compound A (2-BE on ceiling strips), B (ethylene glycol in paint) & E (MTBE) Metabolite: Butoxyacetic Acid


Notes

  • Compound A: 2-BE
  • Metabolite: butoxyacetic acid (primary), butoxyethanol glucuronide, butoxyethanol sulfate
  • Mode of Action: liver and spleen
  • Mode of Action: Bone Marrow
  • Data gaps: No models for #1 aerosolization of contaminant during fueling, #3 release of contaminant from internal combustion engine, #8 partitioning between vapor and particle phase, #13 particle resuspension from surfaces (especially floors), #20 splashes during fueling or painting, #21 Fuel spill frequency/volume, #22 Paint spill frequency/volume, or #23 Mainstream smoking (may be able to use something from review article on smoking release from website http://ehpnet1.niehs.nih.gov/docs/1999/Suppl-2/375-381ott/abstract.html)
  • Dr. John Little and others at Virginia Tech in Blacksburg, VA have developed diffusion algorithms for VOCs that may be an improvement over existing models for diffusion-controlled release in process #1 and the reversible, diffusive sink effect for processes #6, #7, & #8. Papers describing these algorithms have recently been accepted in the journals "Indoor Air" and " Environmental Science & Technology". Dr. Little's e-mail address is jcl@vt.edu.

Return to Process Framework list.