Comprehensive Chemical Exposure Framework

Title Page

1.0 Introduction

2.0 Literature Review

3.0 Model Framework

4.0 Scenarios
4.1 Life Stages
4.2 Scenario 1
    Model Flow Diagram 1
4.3 Scenario 2
    Model Flow Diagram 2
4.4 Scenario 3
    Model Flow Diagram 3
4.5 Scenario 4
    Model Flow Diagram 4
4.6 Process Flow
4.7 Gap Analysis

5.0 Qualitative Analysis

6.0 Recommendations

7.0 References

Appendix A

4.2 Scenario 1



Figure 4.2.1  Life Stages For Exposure Scenario 1


Scenario 1
Scenario 2
Scenario 3
Scenario 4

Scenario 1

This section provides the conceptual model for the exposure pathways associated with Exposure Scenario 1. The conceptual model and associated assumptions are critical in determining the type of the models, algorithms, and databases required to satisfy the needs of the modeling scenario. Figure 4.2.2 provides an illustration of the conceptual model for Exposure Scenario 1.

Residential Indoor Description
- 1-story Townhouse with 1700 ft2 in MA
- Electric heat pump, forced air and AC
- 3 bedrooms, 1.5 baths, kitchen, living & dining rooms

Exposure in Home to SVOC Compounds A & B
- Compound A: 2-butoxyethanol applied in mineral spirits solution by immersion of wooden strip ceiling at factory
- Infant born 12 months after moving into home
- Mother stays at home and nurses baby

- Compound B: ethylene glycol contained in latex wall paint
- Entire living space painted when moved into home (-1 year) and repainted 1 wk after baby arrives

Scenario 1 Picture

Figure 4.2.2  Illustration Depicting The Setting For Exposure Scenario 1 In Study


Assumptions about Exposure and Activities
- Embryo embedded at day 11 after fertilization
- Normal length of pregnancy (9 months)
- Nursing from birth until 0.5 yrs (6 months)
- Repaint home when child is age 4

Child Age Timeline
- Fetus (-0.75 years until birth)
- Newborn (birth to 0.25 yrs) (3 months)
- Infant (0.25-2 years)
- Toddler (2-3 years)
- Early Childhood (3-6 years)

Notes
- Health effects will be calculated for the fetus through child. Depending on model outputs, this can be a cumulative time distribution or a time-weighted value.
- The infant is born 12 months after moving into home.
- The mother works at home and nurses baby.
- There will be a spiked increase in ethylene glycol at week 1 when fresh paint is applied over the entire living space.

Figure 4.2.3  CCEF Model Flow Diagram Scenario 1