Comprehensive Chemical Exposure Framework

Title Page

1.0 Introduction

2.0 Literature Review

3.0 Model Framework

4.0 Scenarios
4.1 Life Stages
4.2 Scenario 1
    Model Flow Diagram 1
4.3 Scenario 2
    Model Flow Diagram 2
4.4 Scenario 3
    Model Flow Diagram 3
4.5 Scenario 4
    Model Flow Diagram 4
4.6 Process Flow
4.7 Gap Analysis

5.0 Qualitative Analysis

6.0Recommendations

7.0 References

Appendix A

The following Scenario 1 Process Flow Diagram illustrates
the mapping between the models and the process numbers.
Select a model or model description from the table below (ordered alphabetically),
and the corresponding processes on the diagram will be highlighted.
Fetus Compound A Exposure
CONTAMW
Dust resuspension
IAQX
Partitioning between vapor and particle phase
PBPD for human
PBPK for human
THERdbASE

Figure 4.6.1 Scenario 1 Process Framework: Exposure of Compound A (2-BE on ceiling strips) to fetus via mother


Notes

  • Compound A: 2-BE
  • Metabolite: butoxyacetic acid (primary), butoxyethanol glucuronide, butoxyethanol sulfate
  • Mode of Action: fetal effects, maternal liver and spleen
  • Pregnant/Nursing Mother: 2-methoxyethanol models based on mouse/rat studies
  • Adult male PBPK available – need to scale & adapt for child
  • Data gap: No models for #5 partitioning between vapor and particle phase or #10 particle resuspension from surfaces (especially floors)
  • Data gaps: no maternal/fetal PBPK for 2-BE
  • Dr. John Little and others at Virginia Tech in Blacksburg, VA have developed diffusion algorithms for VOCs that may be an improvement over existing models for diffusion-controlled release in process #1 and the reversible, diffusive sink effect for processes #6, #7, & #8. Papers describing these algorithms have recently been accepted in the journals "Indoor Air" and " Environmental Science & Technology". Dr. Little's e-mail address is jcl@vt.edu.
Return to Process Framework list.