Comprehensive Chemical Exposure Framework

Title Page

1.0 Introduction

2.0 Literature Review

3.0 Model Framework

4.0 Scenarios
4.1 Life Stages
4.2 Scenario 1
    Model Flow Diagram 1
4.3 Scenario 2
    Model Flow Diagram 2
4.4 Scenario 3
    Model Flow Diagram 3
4.5 Scenario 4
    Model Flow Diagram 4
4.6 Process Flow
4.7 Gap Analysis

5.0 Qualitative Analysis

6.0Recommendations

7.0 References

Appendix A

The following Scenario 4 Process Flow Diagram illustrates
the mapping between the models and the process numbers.
Select a model or model description from the table below (ordered alphabetically),
and the corresponding processes on the diagram will be highlighted.
Glycolic acid and Oxalic Acid Metabolites
CONTAMW
Dust resuspension
Fuel spill frequency & volume
IAQX for Compound A
indoor smoke emission
Micro-Environmental Air Transport Outdoors
Paint spill frequency & volume
Partitioning between vapor and particle phase
PBPD for adult male
PBPK for adult male
PROMISE for Spills from Compounds B and E
Source emission model(s) for fueling, combustion and servicing
THERdbASE
WPEM for Compound B

Figure 4.6.13 Scenario 4 Process Framework: Exposure of Father to Compound A (2-BE on ceiling strips),B (ethylene glycol in paint) & E (MTBE) Metabolites: Glycolic Acid and Oxalic Acid


Notes

  • Compound B: Ethylene Glycol
  • Metabolite: Glycolic Acid, Oxalic Acid
  • Mode of Action: developing embryo, Kidney
  • Data gaps: No models for #1 aerosolization of contaminant during fueling, #3 release of contaminant from internal combustion engine, #8 partitioning between vapor and particle phase, #13 particle resuspension from surfaces (especially floors), #20 splashes during fueling or painting, #21 Fuel spill frequency/volume, #22 Paint spill frequency/volume, or #23 Mainstream smoking (may be able to use something from review article on smoking release from website http://ehpnet1.niehs.nih.gov/docs/1999/Suppl-2/375-381ott/abstract.html)
  • Dr. John Little and others at Virginia Tech in Blacksburg, VA have developed diffusion algorithms for VOCs that may be an improvement over existing models for diffusion-controlled release in process #1 and the reversible, diffusive sink effect for processes #6, #7, & #8. Papers describing these algorithms have recently been accepted in the journals "Indoor Air" and " Environmental Science & Technology". Dr. Little's e-mail address is jcl@vt.edu.

Return to Process Framework list.