4.0 Scenarios
4.1 Life Stages
4.2 Scenario 1
Model Flow Diagram 1
4.3 Scenario 2
Model Flow Diagram 2
4.4 Scenario 3
Model Flow Diagram 3
4.5 Scenario 4
Model Flow Diagram 4
4.6 Process Flow
4.7 Gap Analysis
| Diagram Legend | |
|---|---|
| Solid boxes | Models with known codes available |
| Dashed boxes | Models with codes not available |
| Ovals | Input/output files with specific data specifications |
| Checkered Ovals | Output from separate scenario/input to this scenario |
| Cylinders | Model-Specific databases |
| Arrows | Indicates the flow of the data |
| PBPK | Physiologically-based Pharmacokinetics |
| PBPD | Physiologically-based Pharmacodynamics |
Notes
- Note that there is a PBPK or PBPD model for each of the three chemicals of concern, but these were developed specifically for an adult male. It may be possible to adapt for a child using different physiological parameters.
- It should also be noted that possible interactions and competing modes of action, could be incorporated into a PBPD model depending on available information
- LifeLine, CARES, and other lifestyle aggregate codes will overlay onto the PBPK and PBPD models.
- Indoor air transport modeling (SVOC emission) can be handled by many models, we selected CONTAM for this case because it can handle aerosols. However, there are at least 4 other models identified in the literature review that could be used. Some of the transport models are planning to add aerosol and particle deposition components, and in some cases, separate models could handle deposition to product surface concentrations.
- THERdbASE is used to estimate human activity patterns and exposure doses. We would prefer to use LifeLine, Cares and other multi-route, multi-source models but it is difficult to integrate them because they are proprietary and much of the needed information is not readily available.
- DEPM includes information on food intake for estimating dietary exposure.
- CHAD is a master database that provides information on human activity.
- EPA’s Exposure Factors Handbook for adults (http://www.epa.gov/ncea/exposfac.htm) and the Child-Specific Exposure Factors Handbook will be usedas appropriate.
- CONSEXPO includes hand-to-mouth, leaching from objects in mouth, and leaching of contaminants into food items.
