Comprehensive Chemical Exposure Framework

Title Page

1.0 Introduction

2.0 Literature Review

3.0 Model Framework

4.0 Scenarios
4.1 Life Stages
4.2 Scenario 1
    Model Flow Diagram 1
4.3 Scenario 2
    Model Flow Diagram 2
4.4 Scenario 3
    Model Flow Diagram 3
4.5 Scenario 4
    Model Flow Diagram 4
4.6 Process Flow
4.7 Gap Analysis

5.0 Qualitative Analysis

6.0Recommendations

7.0 References

Appendix A

The following Scenario 2 Process Flow Diagram illustrates
the mapping between the models and the process numbers.
Select a model or model description from the table below (ordered alphabetically),
and the corresponding processes on the diagram will be highlighted.
Newborn DEHP Exposure
CONSEXPO
CONTAMW
Dust resuspension
Partitioning between vapor and particle phase
PBPD for human
PBPK for human
THERdbASE

Figure 4.6.7 Scenario 2 Process Framework: Exposure of Compound C (DEHP or BBP or DINP) to newborn (or nursing infant) directly and via mother through milk


Notes

  • Compound C: DEHP: diethyl hexyl phthalate
  • Metabolite: Not Known
  • Mode of Action: Not Known
  • Data gap: No models for #5 partitioning between vapor and particle phase or #10 particle resuspension from surfaces (especially floors)
  • Data gap: newborn and nursing infant PBPK or PBPD for DEHP

  • Compound C: BBP: butyl benzyl phthalate
  • Metabolite: Not found during literature search
  • Mode of Action: Not found during literature search
  • Data gap: No models for #5 partitioning between vapor and particle phase or #10 particle resuspension from surfaces (especially floors)
  • Data gap: nursing infant PBPK for BBP

  • Compound C: DINP: diisononyl phthalate
  • Metabolite: Not Known
  • Mode of Action: Not Known
  • Data gap: No models for #5 partitioning between vapor and particle phase or #10 particle resuspension from surfaces (especially floors)
  • Data gap: newborn and nursing infant PBPK for DINP

Return to Process Framework list.