Comprehensive Chemical Exposure Framework

Title Page

1.0 Introduction

2.0 Literature Review

3.0 Model Framework
3.1 Objectives
3.2 Approach
3.3 Requirements
3.4 Design
3.5 Data Exchange Protocol

4.0 Scenarios

5.0 Qualitative Analysis

6.0 Recommendations

7.0 References

Appendix A

3.1 CCEF OBJECTIVES

The purpose of this research is twofold: design an overarching framework that is comprehensive, logical, and useful for industrial needs; and within that framework identify research needs based on gap and sensitivity analyses. The overarching framework, called the Comprehensive Chemical Exposure Framework, will be used to house models, algorithms, and databases associated with micro-environmental exposure modeling. The research needs are defined for representative high volume compounds that could be involved in exposure scenarios.

The Attributes for the CCEF are listed here with a detailed description in the Requirements section.

· Comprehensive
· Modular
· User-friendly
· Multi-route, Multi-pathway, & Multi-source for Varying durations
· Accurate
· Open code
· Probabilistic
· Dose-responsive
· Mass-conservative