Comprehensive Chemical Exposure Framework

Title Page

1.0 Introduction

2.0 Literature Review

3.0 Model Framework

4.0 Scenarios
4.1 Life Stages
4.2 Scenario 1
    Model Flow Diagram 1
4.3 Scenario 2
    Model Flow Diagram 2
4.4 Scenario 3
    Model Flow Diagram 3
4.5 Scenario 4
    Model Flow Diagram 4
4.6 Process Flow
4.7 Gap Analysis

5.0 Qualitative Analysis

6.0Recommendations

7.0 References

Appendix A

The following Scenario 1 Process Flow Diagram illustrates
the mapping between the models and the process numbers.
Select a model or model description from the table below (ordered alphabetically),
and the corresponding processes on the diagram will be highlighted.
Fetus Compound B Exposure
CONTAMW
Dust resuspension
Partitioning between vapor and particle phase
PBPD for human
PBPK for human
THERdbASE
WPEM

Figure 4.6.4 Scenario 1 Process Framework: Exposure of Compound B (ethylene glycol) to fetus via mother


Notes

  • Compound B: Ethylene Glycol
  • Metabolite: methoxyacetic acid
  • Mode of Action: effects on the developing embryo, adult kidney
  • Data gap: No models for #5 partitioning between vapor and particle phase or #10 particle resuspension from surfaces (especially floors)
  • Validation of ethylene glycol PBPK models in the human pregnant females, currently has only been partially validated in males (Gargas, et al. 2000)
  • PBPK model not validated in the child
  • Dr. John Little and others at Virginia Tech in Blacksburg, VA have developed diffusion algorithms for VOCs that may be an improvement over existing models for diffusion-controlled release in process #1 and the reversible, diffusive sink effect for processes #6, #7, & #8. Papers describing these algorithms have recently been accepted in the journals "Indoor Air" and " Environmental Science & Technology". Dr. Little's e-mail address is jcl@vt.edu.

Return to Process Framework list.